Karyotype is a "genetic passport" of a person, which includes all data about the number, size and shape of the chromosomes. Changes in the karyotype are representing a variety of mutations and chromosomal numerical disturbance. With a high chance, those may lead to the transmission of genetic diseases to the unborn baby, infertility and miscarriage diagnosis. Karyotype analysis is an important step in preparation for pregnancy.
Polymorphisms investigation is a specific examination that determines the risk of developing a number of diseases in the adult. During such examination, the functionality of a present genome of the particular adult is tested helping to predict which diseases could be transmissed to the child. Results of the analysis represent a special report, which helps doctor to create a proper therapy to make pregnancy safe for both mother and a child.
Male's AZF region of the Y chromosome is responsible not simply for a man's identity and sex, but it constitutes the normal process of spermatogenesis. Microdeletions in AZF region has been shown to cause male infertility since the process of sperm synthsis is disrupted, which causes poor qualuty of gametes, altered shape and integrity or even resulting in a complete abortion of sperm production.
PGD is a type of examination that determines the risk of developing a number of diseases in the child, which is made proir to the implantation of an embryo to the uterine wall of a woman. The key moment about such investigation is that the general structure of chromosomes, their number and pairness are observed. Moreover, it helps to evaluate the likelihood of miscarriage, development of fetal pathology or a birth of a child with genetic pathology.
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